Bibliometric Analysis of Global Research Trends on the Antidiabetic Potential of Andaliman (Zanthoxylum armatum DC.)

Main Article Content

Muhammad Ainur Rosyid Ridho
Ratri Dwi Indriani
Restu Hidayanti

Abstract

This study presents a bibliometric analysis of global research trends concerning the antidiabetic potential of Zanthoxylum armatum DC. Data were retrieved from the Scopus database and analyzed using VOSviewer to map keywords, thematic clusters, and research evolution. The findings highlight a strong focus on antidiabetic effects and the pharmacological activity of bioactive compounds such as alkylamides, flavonoids, and phenolics, which act through mechanisms including inhibition of α-glucosidase and α-amylase, activation of the AMPK pathway, and enhancement of glucose transport. The visualizations also reveal the incorporation of Z. armatum into low-glycemic functional foods. This study underscores the plant’s promising role in natural diabetes therapy and the value of bibliometric approaches in systematically evaluating research landscapes.

Article Details

How to Cite
Rosyid Ridho, M. A., Indriani, R. D., & Hidayanti, R. (2025). Bibliometric Analysis of Global Research Trends on the Antidiabetic Potential of Andaliman (Zanthoxylum armatum DC.). JURNAL KESEHATAN, SAINS, DAN TEKNOLOGI (JAKASAKTI), 4(2), 746–759. Retrieved from https://jurnal.undhirabali.ac.id/index.php/jakasakti/article/view/4279
Section
Articles

References

Ahmadi, S., Ahmadi, G., & Ahmadi, H. (2022). A review on antifungal and antibacterial activities of some medicinal plants. Micro Nano Bio Aspects, 1(1), 10-17. https://doi.org/10.22034/mnba.2022.150563

Amin, A., Shah, R., & Varghese, J. (2023). Alkylamides from Zanthoxylum species: Molecular docking and pharmacokinetic analysis for type 2 diabetes management. Journal of Ethnopharmacology, 316, 116781. https://doi.org/10.1016/j.jep.2023.116781

Aria, M., & Cuccurullo, C. (2017). bibliometrix: An R-tool for comprehensive science mapping analysis. Journal of Informetrics, 11(4), 959–975. https://doi.org/10.1016/j.joi.2017.08.007

Arokiasamy, P., Salvi, S., & Selvamani, Y. (2021). Global burden of diabetes mellitus. In Handbook of global health (pp. 1-44). Cham: Springer International Publishing. https://doi.org/10.1007/978-3-030-05325-3_28-1

Barrett, A. H., Farhadi, N. F., & Smith, T. J. (2018). Slowing starch digestion and inhibiting digestive enzyme activity using plant flavanols/tannins—A review of efficacy and mechanisms. Lwt, 87, 394-399. https://doi.org/10.1016/j.lwt.2017.09.002

Baynes, H. W. (2015). Classification, pathophysiology, diagnosis and management of diabetes mellitus. J diabetes metab, 6(5), 1-9. https://doi.org/10.4172/2155-6156.1000541

Carmo de Carvalho e Martins, M. D., da Silva Santos Oliveira, A. S., da Silva, L. A. A., Primo, M. G. S., & de Carvalho Lira, V. B. (2022). Biological indicators of oxidative stress [malondialdehyde, catalase, glutathione peroxidase, and superoxide dismutase] and their application in nutrition. In Biomarkers in nutrition (pp. 833-856). Cham: Springer International Publishing. https://doi.org/10.1007/978-3-031-07389-2_49

Deacon, C. F., & Lebovitz, H. E. (2016). Comparative review of dipeptidyl peptidase‐4 inhibitors and sulphonylureas. Diabetes, Obesity and Metabolism, 18(4), 333-347. https://doi.org/10.1111/dom.12610

Donthu, N., Kumar, S., Mukherjee, D., Pandey, N., & Lim, W. M. (2021). How to conduct a bibliometric analysis: An overview and guidelines. Journal of Business Research, 133, 285–296. https://doi.org/10.1016/j.jbusres.2021.04.070

Gondokesumo, M. E., Kusuma, H. S. W., & Widowati, W. (2017). α-/β-glucosidase and α-amylase inhibitory activities of roselle (Hibiscus sabdariffa L.) ethanol extract. Molecular and Cellular Biomedical Sciences, 1(1), 34-40. https://doi.org/10.21705/mcbs.v1i1.3

Hassan, M. A., & Duarte, P. (2024). Mapping scientific landscapes: The role of bibliometric analysis in ethnopharmacological research. Frontiers in Pharmacology, 15, 1287334. https://doi.org/10.3389/fphar.2024.1287334

Hassan, W., & Duarte, A. E. (2024). Bibliometric analysis: a few suggestions. Current problems in cardiology, 49(8), 102640.

Hong, F., Pan, S., Guo, Y., Xu, P., & Zhai, Y. (2019). PPARs as nuclear receptors for nutrient and energy metabolism. Molecules, 24(14), 2545. https://doi.org/10.3390/molecules24142545

Kim, H. J., & Park, S. Y. (2024). Regulation of hepatic gluconeogenesis and lipid metabolism by Zanthoxylum piperitum extract via AMPK activation. Phytomedicine, 127, 155284. https://doi.org/10.1016/j.phymed.2023.155284

Kong, C. C., Cheng, J. D., & Wang, W. (2023). Neurotransmitters regulate β cells insulin secretion: a neglected factor. World Journal of Clinical Cases, 11(28), 6670. https://doi.org/10.12998/wjcc.v11.i28.6670

Kumar, S., & Chakravarty, S. (2018). Amylases. In Enzymes in human and animal nutrition (pp. 163-180). Academic Press. https://doi.org/10.1016/B978-0-12-805419-2.00008-3

Lee, Y. J., Oh, E., & Jeong, H. (2023). Anti-hyperglycemic effects of Zanthoxylum piperitum through modulation of AMPK and GLUT4 pathways in diabetic mice. Frontiers in Pharmacology, 14, 1219805. https://doi.org/10.3389/fphar.2023.1219805

Li, X., Bai, Y., Jin, Z., & Svensson, B. (2022). Food-derived non-phenolic α-amylase and α-glucosidase inhibitors for controlling starch digestion rate and guiding diabetes-friendly recipes. Lwt, 153, 112455. https://doi.org/10.1016/j.lwt.2021.112455

Lim, W. M., & Kumar, S. (2024). Bibliometric and content analysis in health sciences: Trends and thematic evolution. Scientometrics, 129(2), 547–565. https://doi.org/10.1007/s11192-024-04987-2

Mawthoh, A. B., Seram, D., Singh, K. A., & Watt, H. J. (2023). Applications of Prickly Ash (Zanthoxylum spp.): Potential in Traditional Science. Modern Science, and Agriculture. Journal of Food Chemistry and Nanotechnology, 9(S1), S117-S131. https://doi.org/10.17756/jfcn.2023-S1-016

Okagu, I. U., Ndefo, J. C., Aham, E. C., & Udenigwe, C. C. (2021). Zanthoxylum species: a comprehensive review of traditional uses, phytochemistry, pharmacological and nutraceutical applications. Molecules, 26(13), 4023. https://doi.org/10.3390/molecules26134023

Omar, B., & Ahrén, B. (2014). Pleiotropic mechanisms for the glucose-lowering action of DPP-4 inhibitors. Diabetes, 63(7), 2196-2202. https://doi.org/10.2337/db14-0052

Pechmann, L. M., Pinheiro, F. I., Andrade, V. F. C., & Moreira, C. A. (2024). The multiple actions of dipeptidyl peptidase 4 (DPP-4) and its pharmacological inhibition on bone metabolism: a review. Diabetology & Metabolic Syndrome, 16(1), 175. https://doi.org/10.1186/s13098-024-01412-x

Peres, M., Costa, H. S., Silva, M. A., & Albuquerque, T. G. (2023). The health effects of low glycemic index and low glycemic load interventions on prediabetes and type 2 diabetes mellitus: a literature review of RCTs. Nutrients, 15(24), 5060. https://doi.org/10.3390/nu15245060

Rahman, M. M., Khatun, M., & Roy, D. (2023). Functional food applications of Zanthoxylum piperitum leaf powder in glycemic control: Clinical and biochemical perspectives. Food Bioscience, 52, 102377. https://doi.org/10.1016/j.fbio.2023.102377

Salehi, B., Zakaria, Z. A., Gyawali, R., Ibrahim, S. A., Rajkovic, J., Shinwari, Z. K., ... & Setzer, W. N. (2019). Piper species: A comprehensive review on their phytochemistry, biological activities and applications. Molecules, 24(7), 1364. https://doi.org/10.3390/molecules24071364

Shah, A., Yadav, A., & Joshi, N. (2024). Multifunctional potential of Zanthoxylum species: From traditional medicine to vector control. Environmental Science and Pollution Research, 31(4), 3932–3945. https://doi.org/10.1007/s11356-024-29218-9

Song, S., Oh, S., & Lim, K. T. (2015). Bioactivity of proteins isolated from Lactobacillus plantarum L67 treated with Zanthoxylum piperitum DC glycoprotein. Letters in applied microbiology, 60(6), 597-604. https://doi.org/10.1111/lam.12416

Tyagi, S., Gupta, P., Saini, A. S., Kaushal, C., & Sharma, S. (2011). The peroxisome proliferator-activated receptor: A family of nuclear receptors role in various diseases. Journal of advanced pharmaceutical technology & research, 2(4), 236-240. DOI: 10.4103/2231-4040.90879

Verma, K. K., Kumar, B., Raj, H., & Sharma, A. (2021). A review on chemical constituents, traditional uses, pharmacological studies of Zanthoxylum armatum (rutaceae). J. Drug Deliv. Ther, 11(2-S), 136-142. http://dx.doi.org/10.22270/jddt.v11i2-s.4786

Wondmkun, Y. T. (2020). Obesity, insulin resistance, and type 2 diabetes: associations and therapeutic implications. Diabetes, Metabolic Syndrome and Obesity, 3611-3616. https://doi.org/10.2147/DMSO.S275898

Xu, Y., Huang, J., Wang, N., Tan, H. Y., Zhang, C., Li, S., ... & Feng, Y. (2021). Network pharmacology–based analysis and experimental exploration of antidiabetic mechanisms of gegen Qinlian decoction. Frontiers in Pharmacology, 12, 649606. https://doi.org/10.3389/fphar.2021.649606

Yan, L., & Zhiping, W. (2023). Mapping the literature on academic publishing: A bibliometric analysis on WOS. Sage Open, 13(1), 21582440231158562. https://doi.org/10.1177/21582440231158562

Youssef, M. E., Shehtou, G., Abdelkader, E., & EL-Abasy, H. (2025). Cardioprotective Mechanisms of Metformin: A Review of Molecular Pathways and Therapeutic Implications Beyond Glycemic Control. Delta University Scientific Journal, 8(1), 32-39. https://dx.doi.org/10.21608/dusj.2025.356991.1120

Zain, H. H. M. (2024). Bibliometric Analysis of Global Research Trends on Plant Extract in Antidiabetic Research Using the Scopus Database. Journal of Science and Mathematics Letters, 12(2), 134-141.

Zain, R. A. (2024). Global trends in medicinal plant research: A bibliometric overview of Zanthoxylum genus and its therapeutic applications. Plants, 13(3), 589. https://doi.org/10.3390/plants13030589

Zeng, M., van Pijkeren, J. P., & Pan, X. (2023). Gluco‐oligosaccharides as potential prebiotics: Synthesis, purification, structural characterization, and evaluation of prebiotic effect. Comprehensive Reviews in Food Science and Food Safety, 22(4), 2611-2651. https://doi.org/10.1111/1541-4337.13156

Zhang, Y., Wang, X., Liu, J., & Li, H. (2021). Insights into the antidiabetic potential of traditional medicinal plants: Mechanisms and challenges. Phytotherapy Research, 35(3), 1243–1257. https://doi.org/10.1002/ptr.6874

Zhou, R., Li, T., & Sun, X. (2024). Phenolic compounds from Zanthoxylum piperitum attenuate lipid peroxidation and improve insulin signaling in obese-diabetic rats. Phytomedicine Plus, 4(2), 100395. https://doi.org/10.1016/j.phyplu.2023.100395