The Relationship between Uric Acid Levels and Fatigue in Gout Arthritis Patients at the Sawah Besar Community Health Center, Central Jakarta
Article Sidebar
Main Article Content
Abstract
Gout Arthritis is an inflammatory joint disease caused by the accumulation of uric acid crystals due to impaired purine metabolism. In addition to causing joint pain and swelling, this condition also has an impact on fatigue which can reduce the quality of life of sufferers. High uric acid levels contribute to chronic inflammation that can impair muscle function, decrease energy, and worsen fatigue both physically and psychologically. However, there have been few studies that specifically examine the relationship between uric acid levels and fatigue, especially at the primary health care level such as community health centers. This study used a quantitative approach with a cross-sectional design. A total of 79 respondents with Gout Arthritis at the Sawah Besar Community Health Center were selected using a purposive sampling technique. Uric acid level data were obtained through direct examination using the point of-care uric acid test, while fatigue was measured using the Multidimensional Fatigue Inventory (MFI-20) questionnaire. The relationship between variables was analyzed using the Pearson correlation test. The results showed that the majority of respondents experienced hyperuricemia and moderate to high levels of fatigue. The results of the correlation test showed a significant relationship between uric acid levels and fatigue with a p-value (0.018) and r value = 0.267 which indicates that the higher the uric acid levels, the higher the fatigue experienced by sufferers, these results confirm the importance of managing other factors such as pain, sleep quality, and stress in nursing management of Gout patients.
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
References
Alhammadi, N. A., Jan, A. R. A., Lujain, S. A., Aljohani, S. M., Alharthi, N. N., & Almalki, A. E. (2024). Health‑related quality of life in gout patients in Madinah Region, Saudi Arabia. Journal of Family Medicine and Primary Care, 13(6). https://doi.org/10.4103/jfmpc.jfmpc_1393_23
Arsa, P. S. A. (2021). Profil Karakteristik Individu Terhadap Kejadian Hiperuresemia. Jurnal Ilmiah Kesehatan Media Husada, 10(1), 28–33. https://doi.org/10.33475/jikmh.v10i1.244
Bergsten, U., Dehlin, M., Klingberg, E., Landgren, A. J., & Jacobsson, L. T. H. (2023). Gender differences in illness perceptions and disease management in patients with gout, results from a questionnaire study in Western Sweden. BMC Musculoskeletal Disorders, 24(1), 1–8. https://doi.org/10.1186/s12891-023-06416-8
Cha, Y., Lee, J., Choy, W., Lee, J. S., Lee, H. H., & Chae, D. S. (2024). Pathophysiology and Treatment of Gout Arthritis; including Gout Arthritis of Hip Joint: A Literature Review. Hip and Pelvis, 36(1), 1–11. https://doi.org/10.5371/hp.2024.36.1.1
Chung, P.-T., Ma, H.-C., Huang, S.-Y., Lien, H.-N., Ho, K.-H., Hsu, H.-Y., Hwang, L.-C., Tsou, M.-T., Tsou, M.-T., Lin, H.-H., & Chan, H.-L. (2023). Association between serum uric acid levels and bone mineral density in patients with osteoporosis: a cross-sectional study. BMC Musculoskeletal Disorders, 24(1). https://doi.org/10.1186/s12891-023-06414-w
Cross, M., Ong, K. L., Culbreth, G. T., Steinmetz, J. D., Cousin, E., Lenox, H., Kopec, J. A., Haile, L. M., Brooks, P. M., Kopansky-Giles, D. R., Dreinhoefer, K. E., Betteridge, N., Abbasian, M., Abbasifard, M., Abedi, A., Aboye, M. B., Aravkin, A. Y., Artaman, A., Banach, M., … Woolf, A. D. (2024). Global, regional, and national burden of gout, 1990–2020, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021. The Lancet Rheumatology, 6(8), e507–e517. https://doi.org/10.1016/S2665-9913(24)00117-6
Dehlin, M., Muller, S., Mallen, C., Landgren, A. J., Watson, L., Jacobsson, L. T. H., & Roddy, E. (2023). Sex and country differences in gout: cross-country comparison between Sweden and the UK. Scandinavian Journal of Rheumatology, 52(6), 673–682. https://doi.org/10.1080/03009742.2023.2177383
Guo, J., Zhou, W., He, M., Gu, Z., & Dong, C. (2020). Ab1329-Hpr the Current Status and Associated Factors of Fatigue in Chinese Patients With Gout. Annals of the Rheumatic Diseases, 79(Suppl 1), 1953.3-1953. https://doi.org/10.1136/annrheumdis-2020-eular.6338
Ibrahim, Andika, Widodo, & Reski. (2020). Pengaruh Konsumsi Madu Terhadap Kadar Asam Urat Pada Pasien Arthritis Gout di Wilayah Kerja Puskesmas Surantih. Jurnal Kesehatan Saintika Meditory, 3(1), 42–51. https://jurnal.syedzasaintika.ac.id
Ismail, S. S., Watung, G., Sibua, S., & Astuti, W. (2024). Hubungan Kualitas Tidur Dengan Kelelahan Fisik Pada Lansia Di Wilayah Kerja Uptd Puskesmas Motoboi Kecil. Watson Journal of Nursing, 2(2), 14–19.
Kim, S., Xu, Y., Dore, K., Gewurtz, R., Larivière, N., & Letts, L. (2022). Fatigue self-management led by occupational therapists and/or physiotherapists for chronic conditions: A systematic review and meta-analysis. Chronic Illness, 18(3), 441–457. https://doi.org/10.1177/17423953211039783
Landgren, A. J., Klingberg, E., Jacobsson, L. T. H., Bergsten, U., & Dehlin, M. (2023). Health-related quality of life in gout, psoriatic arthritis, rheumatoid arthritis and ankylosing spondylitis, results from a cross-sectional survey in Western Sweden. Scandinavian Journal of Rheumatology, 52(5), 506–518. https://doi.org/10.1080/03009742.2022.2157962
Nursiswati, N., Agustin, F. I., & Hanifa, I. D. (2023). Gambaran Kelelahan pada Klien dan Keluarga dengan Diabetes Melitus. Malahayati Nursing Journal, 5(3), 660–669. https://doi.org/10.33024/mnj.v5i3.8035
Park, S., Bak, S. H., Kim, H. S., & Lee, K. A. (2025). Association between obstructive sleep apnea and hyperuricemia/gout in the general population: a cross-sectional study. BMC Musculoskeletal Disorders, 26(1). https://doi.org/10.1186/s12891-024-08264-6
Perhimpunan Reumatologi Indonesia. (2024). Pedoman Diagnosis dan Tatalaksana Hiperurisemia & Artritis Gout.
Prasetyono, D. S. (2016). Tanda Bahaya dari Tubuh. FLASH BOOKS. https://books.google.co.id/books?id=n7xYEAAAQBAJ
Priyanto, A., Abdillah, A., & J, L. F. (2023). the Correlation Between Physical Activity and Stress and Their Impact on Uric Acid Levels in Older Individuals. International Journal of Nursing and Midwifery Science (Ijnms), 7(3), 387–393. https://doi.org/10.29082/ijnms/2023/vol7/iss3/532
RJ, I., Pailan, E. T., & Baharuddin, B. (2023). Risk Factor Analysis of Gout Arthritis. Jurnal Ilmiah Kesehatan Sandi Husada, 12(1), 157–162. https://doi.org/10.35816/jiskh.v12i1.919
Romadlon, D. S., Huang, H. C., Chen, Y. C., Hu, S. H., Hasan, F., Chiang Morales, M. D., Marta, O. F. D., Al Baqi, S., & Chiu, H. Y. (2022). Fatigue following type 2 diabetes: Psychometric testing of the Indonesian version of the multidimensional fatigue Inventory-20 and unmet fatigue-related needs. PLoS ONE, 17(11 November), 1–12. https://doi.org/10.1371/journal.pone.0278165
Sato, R., & Halling, A. (2024). A combination of unexplained extreme fatigue and weight gain in a previously healthy middle-aged man with moderate alcohol habits , with later diagnosed hyperuricemia , hypertension , diabetes and large bilateral ulcerating heel tophi : a case report. 1–12.
Shang, J., Li, X. H., Lu, S. Q., Shang, Y., Li, L. L., & Liu, B. (2021). Gout of feet and ankles in different disease durations: diagnostic value of single-source DECT and evaluation of urate deposition with a novel semi-quantitative DECT scoring system. Advances in Rheumatology, 61(1). https://doi.org/10.1186/s42358-021-00194-4
Songgigilan, A. M. ., Rumengan, I., & Kundre, R. (2019). Hubungan Pola Makan Dan Tingkat Pengetahuan Dengan Kadar Asam Urat Dalam Darah Pada Penderita Gout Artritis Di Puskesmas Ranotana Weru. Jurnal Keperawatan, 7(1), 1–8. https://doi.org/10.35790/jkp.v7i1.24325
Zha, X., Yang, B., Xia, G., & Wang, S. (2022). Combination of Uric Acid and Pro-Inflammatory Cytokines in Discriminating Patients with Gout from Healthy Controls. Journal of Inflammation Research, 15(February), 1413–1420. https://doi.org/10.2147/JIR.S357159
Zhang, J., Sun, N., Zhang, W., Yue, W., Qu, X., Li, Z., & Xu, G. (2025). The impact of uric acid on musculoskeletal diseases: clinical associations and underlying mechanisms. Frontiers in Endocrinology, 16(February), 1–16. https://doi.org/10.3389/fendo.2025.1515176
Zhou, W., Zhu, J., Guo, J., Chen, H., Zhang, X., Gu, Z., Zhou, F., & Dong, C. (2020). Health-related quality of life assessed by Gout Impact Scale (GIS) in Chinese patients with gout. Current Medical Research and Opinion, 36(12), 2071–2078. https://doi.org/10.1080/03007995.2020.1840341