DIET TINGGI KOLESTEROL MENURUNKAN SEKRESI HORMON TESTOSTERON: STUDI LITERATUR
Article Sidebar
DOI:
Read Counter : 596
Download : 316
Main Article Content
I Gede Widhiantara
I Made Gde Sudyadnyana Sandhika
I Wayan Rosiana
Putu Angga Wiradana
Abstract
Kajian ini bertujuan untuk mengetahui bahwa pola makan tinggi kolesterol menyebabkan kadar kolesterol dalam darah dan jaringan melebihi kadar normal sehingga meningkatkan produksi radikal bebas dalam tubuh terutama lipid peroksida yang merupakan salah satu penyebab infertilitas pada pria. Telah banyak penelitian yang membuktikan hubungan peningkatan radikal bebas dengan gangguan fungsi reproduksi pria khususnya penurunan sekeresi testosteron. Testosteron merupakan hormon reproduksi utama pada pria atau hewan jantan yang dihasilkan melalui proses steroidogenesis pada sel Leydig testis. Dampak tingginya kadar kolesterol dalam darah menurunkan sekresi testosteron antara lain melalui peningkatan produksi radikal bebas sehingga menghambat sekresi Luteinizing Hormone (LH), menghambat enzim-enzim atau protein yang berperan dalam steroidogenesis seperti StAR, enzim sitokrom p450scc, 3β-hydroxysteroid dehydrogenase, 17β- hydroxysteroid dehydrogenase, dan secara seluler merusak morfologi serta fungsi sel Leydig.
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
References
Cai, H., & Harrison, D. G. (2000). The Role of Oxidant Stress. Cirulation research. 78: 840–844.
Calonge, R. N. (2018). Lipid Dysregulation in Seminal and Follicular Fluids could be Related with Male and Female Infertility. Endocrinology&Metabolism International Journal, 6(1). https://doi.org/10.15406/emij.2018.06.00156
Chamindrani Mendis-Handagama, S. M. L., & Siril Ariyaratne, H. B. (2001). Differentiation of the Adult Leydig Cell Population in the Postnatal Testis1. Biology of Reproduction, 65(3), 660–671. https://doi.org/10.1095/biolreprod65.3.660
Cui, L., & Guan, Q. B. (2016). Regulation of lipid metabolism in rat leydig cells testosterone synthesis and proliferation. International Journal of Clinical and Experimental Medicine, 9(5), 8224–8229.
Diwan, A. K. A. N. (2013). the Effect of Taurine on Reproductive Efficiency in Male Rats Fed High Cholesterol Diet. Basrah Journal of Veterinary Research, 12(1), 30–40. https://doi.org/10.33762/bvetr.2013.76186
Firuzi, O., Miri, R., Tavakkoli, M., & Saso, L. (2012). Antioxidant Therapy: Current Status and Future Prospects. Current Medicinal Chemistry, 18(25), 3871–3888. https://doi.org/10.2174/092986711803414368
Haider, S. G. (2007). Leydig cell steroidogenesis: Unmasking the functional importance of mitochondria. Endocrinology, 148(6), 2581–2582. https://doi.org/10.1210/en.2007-0330
Kersten, S., Desvergne, B., & Wahli, W. (2000). Roles of PPARS in health and disease. Nature, 405(6785), 421–424. https://doi.org/10.1038/35013000
Liu, Y., Colby, J. K., Zuo, X., Jaoude, J., Wei, D., & Shureiqi, I. (2018). The role of ppar-δ in metabolism, inflammation, and cancer: Many characters of a critical transcription factor. International Journal of Molecular Sciences, 19(11). https://doi.org/10.3390/ijms19113339
Migliaccio, V., Sica, R., Di Gregorio, I., Putti, R., & Lionetti, L. (2019). High-Fish Oil and High-Lard Diets Differently Affect Testicular Antioxidant Defense and Mitochondrial Fusion/Fission Balance in Male Wistar Rats: Potential Protective Effect of ω3 Polyunsaturated Fatty Acids Targeting Mitochondria Dynamics. International Journal of Molecular Sciences, 20(12). https://doi.org/10.3390/ijms20123110
Niederberger, C. (2017). Re: A High-Fat Diet Impairs Reproduction by Decreasing the IL1β Level in Mice Treated at Immature Stage. The Journal of Urology, Vol. 198, p. 1195. https://doi.org/10.1016/j.juro.2017.09.019
Permatasari, A. A. A. P., & Widhiantara, I. G. (2017). Terapi Testosteron Meningkatkan Jumlah Sel Leydig dan Spermatogenesis Mencit (Mus Musculus) yang Mengalami Hiperlipidemia. Jurnal Media Sains, 1(2), 77–83.
Pinto-Fochi, M. E., Pytlowanciv, E. Z., Reame, V., Rafacho, A., Ribeiro, D. L., Taboga, S. R., & Góes, R. M. (2016). A high-fat diet fed during different periods of life impairs steroidogenesis of rat Leydig cells. Reproduction, 152(6), 795–808. https://doi.org/10.1530/REP-16-0072
Purohit, A., & Daradka, H. M. M. (1999). Effect of mild hyperlipidaemia on testicular cell population dynamics in albino rats. Indian Journal of Experimental Biology, 37(4), 396–398.
Samir Bashandy, A. E. (2007). Effect of fixed oil of Nigella sativa on male fertility in normal and hyperlipidemic rats. International Journal of Pharmacology, Vol. 3, pp. 27–33. https://doi.org/10.3923/ijp.2007.27.33
Setiawan, A. Y. ., Putri, R. ., Indayani, F. ., Widiasih, N. M. ., Anastasia, N., Setyaningsih, D., & Riswanto, F. D. . (2021). Kandungan Kimia dan Potensi Bawang Merah (Allium cepa L.) Sebagai Inhibitor SARS-CoV-2. Analysis Indonesian Journal of Chemometrics and Pharmaceutical, 1(3), 143–155.
Wang, H., Cai, Y., Shao, Y., Zhang, X., Li, N., Zhang, H., & Liu, Z. (2018). Fish oil ameliorates high-fat diet induced male mouse reproductive dysfunction via modifying the rhythmic expression of testosterone synthesis related genes. International Journal of Molecular Sciences, 19(5). https://doi.org/10.3390/ijms19051325
Wang, Y., Nakajima, T., Gonzalez, F. J., & Tanaka, N. (2020). PPARs as metabolic regulators in the liver: Lessons from liver-specific PPAR-null mice. International Journal of Molecular Sciences, 21(6). https://doi.org/10.3390/ijms21062061
Widhiantara, I. G., Sari, N. K. Y., Permatasri, A. A. A. P., & Wiradana, P. A. (2022). Bumbu Bali Si Sedap Yang Sehat Kajian Etnobotani dan Metabolit Sekunder. Yogyakarta: Deepublish.
Widhiantara, I. G., Pangkahila, W.I. & Pangkahila, A. J. (2012). Terapi Testosteron dan LH (Luteinizing hormone) Meningkatkan Jumlah Sel Leydig Mencit (Mus musculus) Yang Menurun Akibat Paparan Asap Rokok. Seminar Nasional MIPA. Universitas Pendidikan Ganesha, Singaraja.
Widhiantara, G., Permatasari, A. A. A. P. & Wiradana, P. A. (2021). the Effect of Sembung Leaf Extract (Blumea balsamifera) on the Number and Diameter of Rats Leydig Cells Induced By High-Fat Diet. Plant Archives, 21(no 1). https://doi.org/10.51470/plantarchives.2021.v21.no1.049
Widhiantara, I. G. (2020). Mutasi DNA Mitokondria Pada Pria Infertil.. Jurnal Media Sains. 4(1), 1–4.
Widhiantara, Permatasari, A. A. A. P., Rosiana, I. W., Sutirtayasa, I. W. P. & Siswanto, F. M. (2020). Role of HIF-1, Siah-1 and SKN-1 in Inducing Adiposity for Caenorhabditis elegans under Hypoxic Conditions. The Indonesian Biomedical Journal, 12(1), 51–56. https://doi.org/10.18585/inabj.v12i1.1007
Widhiantara, I. G., Permatasari, A. A. A. P. & Sutirtayasa, I . W. P. (2021). Spermatogenic and Leydig Cells Induced Hyperlipidemia : A Review. Research Journal of Pharmacy and Technology, 14(October), 5573–5578. https://doi.org/10.52711/0974-360X.2021.00971
Widhiantara, I. G., Permatasari, A. A. A. P., Rosiana, I. W.,Wiradana, P. A., & Satriyasa, B. K. (2021). Steroidogenesis Mechanism, Disruption Factor, Gene Function, and Role in Male Fertility : A Mini Review. Indian Journal of Forensic Medicine & Toxicology, 15(4), 1456–1468. https://doi.org/10.37506/ijfmt.v15i4.16914
Widhiantara I. G. & Jawi I. M. (2022). Antioksidan Alami Sembung (Blumea balsamifera) Sebagai Antihiperkolesterolemia. Yogyakarta: Deepublish.
Widhiantara, I. G., Permatasari, A. A. A. P., Rosiana, I. W., Wiradana, P. A., Widiastini, L. P., & Jawi, I. M. (2021). Antihypercholesterolemic and Antioxidant Effects of Blumea balsamifera L. Leaf Extracts to Maintain Luteinizing Hormone Secretion in Rats Induced by High-Cholesterol Diets. The Indonesian Biomedical Journal, 13(4), 396–402. https://doi.org/10.18585/inabj.v13i4.1694
Widhiantara, I. G., Permatasari, A. A. A. P., Siswanto, F. M., & Dewi, N. P. E. S. (2018). Ekstrak Daun Sembung (Blumea balsamifera) Memperbaiki Histologi Testis Tikus Wistar Yang Diinduksi Pakan Tinggi Lemak. Jurnal Bioteknologi & Biosains Indonesia (JBBI), 5(2), 111. https://doi.org/10.29122/jbbi.v5i2.2868
Yu, C., Jiang, F., Zhang, M., Luo, D., Shao, S., Zhao, J., & Guan, Q. (2019). HC diet inhibited testosterone synthesis by activating endoplasmic reticulum stress in testicular Leydig cells. Journal of Cellular and Molecular Medicine, 23(5), 3140–3150. https://doi.org/10.1111/jcmm.14143
Zmysłowski, A., & Szterk, A. (2017). Current knowledge on the mechanism of atherosclerosis and pro-atherosclerotic properties of oxysterols. Lipids in Health and Disease, 16(1). https://doi.org/10.1186/s12944-017-0579-2