Efektivitas Intervensi Fisioterapi Multimodal Selama Enam Bulan pada Pasien Amyotrophic Lateral Sclerosis (ALS): Laporan Kasus

Main Article Content

Ni Made Nuari Diahputri
Melani
Meka

Abstract

Latar belakang: Amyotrophic Lateral Sclerosis (ALS) adalah penyakit neurodegeneratif progresif yang melibatkan upper motor neuron (UMN) dan lower motor neuron (LMN) tanpa gangguan sensorik, ditandai dengan adanya kelemahan dan atrofi otot, disartria, serta disfagia. Insiden global berkisar 1-2 kasus per 100.000 orang pertahun dengan prevalensi sekitar 6 per 100.000 populasi. Fisioterapi berperan penting melalui pendekatan multimodal yang mencakup latihan penguatan submaksimal, latihan aerobik intensitas rendah, balance training, respiratory muscle training (RMT), dan stretching. Laporan kasus ini bertujuan untuk mengevaluasi efektivitas intervensi fisioterapi multimodal selama enam bulan terhadap fungsi dan kualitas hidup pasien ALS. Metode: Metode yang digunakan dalam penulisan artikel ini adalah laporan kasus yaitu suatu metode deskriptif yang bertujuan untuk memaparkan secara sistematis dan komprehensif mengenai kondisi klinis pasien. Laporan kasus ini telah memperoleh persetujuan dari pasien, dan informed consent tertulis telah diperoleh. Hasil: Evaluasi menggunakan ALSFRS-R menunjukkan adanya penurunan skor sesuai progresi alami penyakit, dari nilai awal 34/48 menjadi 32/48 setelah enam bulan intervensi. Nilai FSS tetap stabil pada skor 4/7. Uji 6MWT menunjukkan penurunan daya tahan dari 320meter menjadi 270meter yang mengindikasikan penurunan ringan. Penilaian keseimbangan melalui TUG meningkat dari 14 detik menjadi 18 detik, sedangkan BBS sedikit menurun dari 42/56 menjadi 41/56. Pemeriksaan MMT menunjukkan penurunan minimal kekuatan otot ekstremitas setalah enam bulan intervensi. Kesimpulan: Meskipun tidak menghentikan progresivitas penyakit, fisioterapi multimodal berkontribusi dalam mempertahankan kapasitas fungsional dan memperlambat penurunan fungsi, sehingga intervensi fisioterapi ikut berperan dalam menjaga kualitas hidup pasien ALS

Article Details

How to Cite
Diahputri, N. M. N., Melani Karang, N. N., & Meka Raini, P. A. (2026). Efektivitas Intervensi Fisioterapi Multimodal Selama Enam Bulan pada Pasien Amyotrophic Lateral Sclerosis (ALS): Laporan Kasus. Jurnal Kesehatan Terpadu, 10(1), 73–84. Retrieved from https://jurnal.undhirabali.ac.id/index.php/kesehatan/article/view/5426
Section
Articles

References

Alves, I., Gromicho, M., Oliveira Santos, M., Pinto, S., & de Carvalho, M. (2025). Assessing disease progression in ALS: prognostic subgroups and outliers. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 26(1–2), 58–63. https://doi.org/10.1080/21678421.2024.2407412

Ammarah Y, S., Michelle E, K., Vanina Dal, B.-H., & Lori, L. (2017). The Impact of Rehabilitation Interventions on Quality of Life in Individuals with Amyotrophic Lateral Sclerosis: A Systematic Review. International Journal of Neurodegenerative Disorders, 1(1), 1–10. https://doi.org/10.23937/ijnd-2017/1710001

Benzo-Iglesias, M. J., Rocamora-Pérez, P., Valverde-Martínez, M. de los Á., García-Luengo, A. V., Benzo-Iglesias, P. M., & López-Liria, R. (2025). Efficacy of respiratory muscle training in improving pulmonary function and survival in patients with amyotrophic lateral sclerosis: a systematic review and meta-analysis. Therapeutic Advances in Respiratory Disease, 19. https://doi.org/10.1177/17534666251346095

Bjelica, B., & Petri, S. (2024). Narrative review of diagnosis, management and treatment of dysphagia and sialorrhea in amyotrophic lateral sclerosis. Journal of Neurology, 271(10), 6508–6513. https://doi.org/10.1007/s00415-024-12657-x

Boomsma, A., Doyle, C., Sai, N., Rogers, M. L., Lee, S. H., & Benyamin, B. (2026). The differences in sex ratio between sporadic and familial amyotrophic lateral sclerosis: a systematic review. Journal of Neurology, 273(2), 92. https://doi.org/10.1007/s00415-026-13627-1

Chang, C. L., Fang, T. P., Tsai, H. M., Chen, H. C., Liu, S. F., Lin, H. L., & Liu, J. F. (2025). Inspiratory muscle training and aerobic exercise for respiratory muscle strength in myasthenia gravis post-hospitalization- a randomized controlled trial. BMC Pulmonary Medicine, 25(1). https://doi.org/10.1186/s12890-025-03733-7

Cheng, J., Niu, X., Li, H., Yang, Q., & Du, K. (2024). Evaluation of the therapeutic effects of rehabilitation therapy on patients with amyotrophic lateral sclerosis—a meta-analysis. Frontiers in Neurology , 15(May), 1–11. https://doi.org/10.3389/fneur.2024.1389146

Fiorella, M. L., Ballini, L., Lavermicocca, V., Ragno, M. S., Restivo, D. A., & Marchese-Ragona, R. (2026). Dysphagia and Dysarthria in Neurodegenerative Diseases: A Multisystem Network Approach to Assessment and Management. Audiology Research, 16(1), 9. https://doi.org/10.3390/audiolres16010009

Fournier, C. N., James, V., & Glass, J. D. (2023). Clinically meaningful change: evaluation of the Rasch-built Overall Amyotrophic Lateral Sclerosis Disability Scale (ROADS) and the ALSFRS-R. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 24(3–4), 311–316. https://doi.org/10.1080/21678421.2022.2153607

Goutman, S. A., Hardiman, O., Al-Chalabi, A., Chió, A., Savelieff, M. G., Kiernan, M. C., & Feldman, E. L. (2022). Recent advances in the diagnosis and prognosis of amyotrophic lateral sclerosis. The Lancet Neurology, 21(5), 480–493. https://doi.org/10.1016/S1474-4422(21)00465-8

Hardiman, O., Al-Chalabi, A., Chio, A., Corr, E. M., Logroscino, G., Robberecht, W., Shaw, P. J., Simmons, Z., & Van Den Berg, L. H. (2017). Amyotrophic lateral sclerosis. Nature Reviews Disease Primers, 3. https://doi.org/10.1038/nrdp.2017.71

Kühnlein, P., Gdynia, H. J., Sperfeld, A. D., Lindner-Pfleghar, B., Ludolph, A. C., Prosiegel, M., & Riecker, A. (2008). Diagnosis and treatment of bulbar symptoms in amyotrophic lateral sclerosis. Nature Clinical Practice Neurology, 4(7), 366–374. https://doi.org/10.1038/ncpneuro0853

Macpherson, C. E., Wani, D. K., Li, H., Rana, V., Blacutt, M., Bello-Haas, V. D., & Quinn, L. (2025). Physical Therapist Interventions for People with Amyotrophic Lateral Sclerosis Across Disease Stages: A Systematic Review of Efficacy. Physical Therapy. https://doi.org/10.1093/ptj/pzaf142

Maier, A., Boentert, M., Reilich, P., Witzel, S., Petri, S., Großkreutz, J., Metelmann, M., Lingor, P., Cordts, I., Dorst, J., Zeller, D., Günther, R., Hagenacker, T., Grehl, T., Spittel, S., Schuster, J., Ludolph, A., & Meyer, T. (2022). ALSFRS-R-SE: an adapted, annotated, and self-explanatory version of the revised amyotrophic lateral sclerosis functional rating scale. Neurological Research and Practice, 4(1). https://doi.org/10.1186/s42466-022-00224-6

Majmudar, S., Wu, J., & Paganoni, S. (2014). Rehabilitation in amyotrophic lateral sclerosis: Why it matters. Muscle and Nerve, 50(1), 4–13. https://doi.org/10.1002/mus.24202

Makwana, L. (2024). Enhancing Mobility and Quality of Life in Patients with Amyotrophic Lateral Sclerosis: The Role of Physical Therapy Interventions. Applied Medical Research, 11(12), 1–5. https://doi.org/10.47363/amr/2024(11)e104

Manjaly, Z. R., Scott, K. M., Abhinav, K., Wijesekera, L., Ganesalingam, J., Goldstein, L. H., Janssen, A., Dougherty, A., Willey, E., Stanton, B. R., Turner, M. R., Ampong, M. A., Sakel, M., Orrell, R. W., Howard, R., Shaw, C. E., Leigh, P. N., & Al-Chalabi, A. (2010). The sex ratio in amyotrophic lateral sclerosis: A population based study. Amyotrophic Lateral Sclerosis, 11(5), 439–442. https://doi.org/10.3109/17482961003610853

Mendes, R. A., Lima, I. L. B., Dourado, M. E. T., & de Jesus Gonçalves, M. (2025). Is there a decline in speech and swallowing in Amyotrophic Lateral Sclerosis over ten years? Codas, 37(2). https://doi.org/10.1590/2317-1782/e20240159en

Meng, L., Li, X., Li, C., Tsang, R. C. C., Chen, Y., Ge, Y., & Gao, Q. (2020). Effects of exercise in patients with amyotrophic lateral sclerosis: A systematic review and meta-analysis. American Journal of Physical Medicine and Rehabilitation, 99(9), 801–810. https://doi.org/10.1097/PHM.0000000000001419

Plowman, E. K., Gray, L. T., Chapin, J., Anderson, A., Vasilopoulos, T., Gooch, C., Vu, T., & Wymer, J. P. (2023). Respiratory Strength Training in Amyotrophic Lateral Sclerosis: A Double-Blind, Randomized, Multicenter, Sham-Controlled Trial. Neurology, 100(15), E1634–E1642. https://doi.org/10.1212/WNL.0000000000206830

Ren, S., Che, X., Hu, S., Feng, X., Zhang, J., & Shi, P. (2025). The effect of exercise intervention on amyotrophic lateral sclerosis: a systematic review and meta-analysis. In Frontiers in Neurology (Vol. 16). Frontiers Media SA. https://doi.org/10.3389/fneur.2025.1499407

Russo, M., Lunetta, C., Zuccarino, R., Vita, G. L., Sframeli, M., Lizio, A., La Foresta, S., Faraone, C., Sansone, V. A., Vita, G., & Messina, S. (2020). The 6-min walk test as a new outcome measure in Amyotrophic lateral sclerosis. Scientific Reports, 10(1), 1–9. https://doi.org/10.1038/s41598-020-72578-3

Ryan G. Brotman, Maria C. Moreno-Escobar, Moreno-Escobar, Joe Joseph, Sunil Munakomi, G. P. (2024). Amyotrophic Lateral Sclerosis. National Center for Biotechnology Information. https://www.ncbi.nlm.nih.gov/sites/books/NBK556151/?utm_source=chatgpt.com

Sanfilippo, M. J., Layshock, M. E., & Keniston, L. (2022). Exploring the association between outcome measures to guide clinical management in patients with amyotrophic lateral sclerosis. Journal of Physical Therapy Science, 34(8), 532–539. https://doi.org/10.1589/jpts.34.532

Silva, S. T., Costa, I. M., Souza, A. A., Pondofe, K., Melo, L. P., Resqueti, V. R., Valentim, R., Gonçalves, F., & Ribeiro, T. S. (2024). Physical therapy for the management of global function, fatigue and quality of life in amyotrophic lateral sclerosis: systematic review and meta-analyses. BMJ Open, 14(8). https://doi.org/10.1136/bmjopen-2023-076541

van Eijk, R. P. A., Weemering, D. N., Opie-Martin, S., van Unnik, J. W. J., Caravaca Puchades, A., Chiò, A., Corcia, P., Galvin, M., Hardiman, O., Heverin, M., Hobin, F., Holmdahl, O., Ingre, C., Lamaire, N., Mac Domhnaill, É., McDonough, H., Manera, U., McDermott, C. J., McFarlane, R., … van den Berg, L. H. (2025). Natural history of the revised ALS functional rating scale and its association with survival: the PRECISION-ALS Extant Study. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 26(sup1), 30–40. https://doi.org/10.1080/21678421.2024.2443985

Wolfson, C., Gauvin, D. E., Ishola, F., & Oskoui, M. (2023). Global Prevalence and Incidence of Amyotrophic Lateral Sclerosis: A Systematic Review. Neurology, 101(6), E613–E623. https://doi.org/10.1212/WNL.0000000000207474

Zhu, Y., Xu, Y., Xuan, R., Huang, J., István, B., Fekete, G., & Gu, Y. (2022). Mixed Comparison of Different Exercise Interventions for Function, Respiratory, Fatigue, and Quality of Life in Adults With Amyotrophic Lateral Sclerosis: Systematic Review and Network Meta-Analysis. Frontiers in Aging Neuroscience, 14(July). https://doi.org/10.3389/fnagi.2022.919059