Pengaruh pH dan Konsentrasi Terhadap Enkapsulasi Metformin HCl pada Monmorillonit Teraktivasi Asam Sitrat

Abstract

ABSTRAK
Monmorillonit telah banyak digunakan sebagai pembawa beberapa jenis obat. Dalam
penelitian ini, metformin HCl dienkapsulasi pada monmorillonit alam pada pH yang berbedabeda

(3 – 10) dan konsentrasi larutan metformin HCl yang bervariasi (50 – 500 mg/L). Sebelum
enkapsulasi, monmorillonit alam diaktivasi terlebih dahulu menggunakan asam sitrat 1 N.
Spektrofotometer FTIR, diffraktometer sinar-X, and N
 Sorption Analyzer digunakan untuk
mengkarakterisasi material hasil aktivasi. Hasil penelitian menunjukkan jumlah metformin HCl
yang terenkapsulasi secara maksimum terjadi pada pH 7.  Uji pengaruh konsentrasi larutan awal
menunjukkan bahwa semakin tinggi konsentrasi larutan, semakin banyak metformin HCl yang
terenkapsulasi pada monmorillonit teraktivasi. Jumlah maksimum metformin HCl yang
terenkapsulasi teramati pada konsentrasi larutan 500 mg/L. Luas permukaan dan volume pori
monmorillonit alam ditemukan menurun setelah aktivasi menggunakan asam sitrat. Analisis
2
menggunakan FTIR menunjukkan pergeseran puncak-puncak serapan monmorillonit setelah
aktivasi dengan asam sitrat. Pergeseran puncak difraksi tidak teramati pada pola difraksi sinar-X
yang mengindikasikan kristalinitas monmorillonit tetap terjaga meskipun setelah diaktivasi
dengan asam sitrat.
Kata kunci: monmorillonit, metformin HCl, pH, konsentrasi awal, enkapsulasi, sistem
penghantar obat
 
ABSTRACT
Montmorillonite has been widely used as a carrier of several drugs.  In this research,
metformin HCl was encapsulated on natural monmorillonite on various pH (3 – 10) and
concentration of metformin HCl (50-500 mg/l). Natural montmorillonite was activated by citric
acid 1 N prior to encapsulation process. FTIR Spectrophotometer, X-ray diffractometer, and N

Sorption Analyzer were used to characterize the materials. The results showed that the highest
amount of metformin HCl encapsulated on natural monmorillonite was occurred at pH of 7. The
effect of initial concentration showed that the higher the concentration of metformin HCl, the
greater the amount of drugs encapsulated on activated monmorillonite. The maximum amount
of drug encapsulated was occurred at initial concentration of 500 mg/L. The surface area and
pore volume of natural monmorillonite were found to be decrease after activation using citric
acid. Analysis using FTIR confirmed the dislocation of absorption peaks after activation with
citric acid. However, the dislocation of diffraction peaks are not observed in XRD pattern,
indicated the there were no changes in the crystallinity of monmorillonit after activation.
Key words: monmorillonite, metformin HCl, pH, initial concentration, encapsulation, drug
delivery system.